Understanding how cells control their size and shape
Official title: Mechanisms controlling cell size and shape
Funded at Dartmouth College · NIH-10934507 · Data updated 2026-11-12
This study is looking at how cells grow and change shape, which is important for keeping them healthy, and it's using a tiny yeast as a model to understand how problems in these processes might lead to diseases like cancer, with the hope of finding new ways to treat those conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $585,939 |
| NIH project number | 5R35GM149248-02 |
| Project ID | NIH-10934507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or conditions related to cell growth and division abnormalities.
✕Less likely to help
Patients with conditions unrelated to cell size and shape, or those not diagnosed with cancer, may not benefit from this research.
What this research studies
This research investigates the molecular and cellular mechanisms that determine the size and shape of cells, which are crucial for normal cell function. By using the fission yeast S. pombe as a model organism, the research aims to uncover how defects in these processes can lead to diseases like cancer. The approach combines various techniques, including genetics and live-cell imaging, to explore how specific proteins and signaling pathways regulate cell growth and division. The ultimate goal is to identify potential therapeutic targets for treating diseases associated with abnormal cell size and shape.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers and other diseases linked to cell size and shape abnormalities.
How similar studies have gone: Other research has shown success in understanding cell cycle regulation and its implications for cancer treatment, making this approach promising.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Moseley, James B — Dartmouth College
- Study coordinator: Moseley, James B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.