Understanding how cells control their genetic messages to make proteins
Dynamics of RNA regulation and noncanonical translation between cell states
This project explores how cells control their genetic messages to build proteins, helping us better understand and target diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11169092 on NIH RePORTER |
What this research studies
Our bodies' cells use genetic instructions (RNA) to make proteins, but sometimes the amount of RNA doesn't match the amount of protein produced, especially in diseases. This project aims to uncover these hidden steps in how cells control their genetic messages, including how RNA is processed and where it goes within the cell. We are particularly interested in how these processes change during disease progression, such as in malignant cells. By mapping these complex regulatory steps, we hope to find new ways to understand why cells behave differently in disease. This deeper understanding could lead to the discovery of new diagnostic tools and unique treatment approaches tailored to specific diseases.
Who could benefit from this research
Good fit: This foundational research does not directly recruit patients, but its findings could eventually help patients with diseases where cell communication and protein production are disrupted.
Not a fit: Patients whose conditions are not related to the fundamental processes of RNA regulation and protein synthesis may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose diseases and develop more effective, targeted treatments by understanding how cells make proteins.
How similar studies have performed: While the general area of RNA and protein regulation is well-studied, this project focuses on poorly understood aspects of post-transcriptional control and unannotated proteins, suggesting a novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Conn, Crystal S — University of Pennsylvania
- Study coordinator: Conn, Crystal S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.