Understanding How Cells Control Their Genes
Structural and Mechanistic basis for RNA Silencing
This project explores how tiny RNA molecules help cells manage their genes, which is important for health and fighting viruses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11144338 on NIH RePORTER |
What this research studies
This project aims to uncover the detailed workings of how small RNA molecules, like piRNAs and miRNAs, control gene activity within our cells. Researchers will use advanced techniques to map the structures of these RNA-protein complexes, revealing how they defend against harmful genetic elements and regulate gene expression. The work also looks at how viruses might hijack these cellular processes to their advantage. By understanding these fundamental mechanisms, we can better grasp how our bodies function and how diseases develop.
Who could benefit from this research
Good fit: This basic science project does not directly involve patient participation but aims to build knowledge that could benefit anyone affected by diseases related to gene regulation or viral infections in the future.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this foundational laboratory research.
Why it matters
Potential benefit: Success in this foundational work could lead to new ways to treat diseases by precisely controlling gene activity or by interfering with how viruses multiply.
How similar studies have performed: This project builds upon existing knowledge in RNA biology and structural biochemistry, aiming to fill critical gaps in understanding these complex cellular processes.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Macrae, Ian John — Scripps Research Institute, the
- Study coordinator: Macrae, Ian John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.