Understanding How Cells Control Their Activities
Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases
This project aims to understand how cells manage their internal signals, particularly focusing on the "off switches" that help control cell division.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-11089427 on NIH RePORTER |
What this research studies
Our bodies rely on a delicate balance of signals to keep cells healthy and dividing correctly. Think of it like a "tug of war" inside each cell, where some signals turn processes on and others turn them off. This project focuses on understanding the "off switches," called phosphatases, which are less understood than the "on switches." By learning more about how these phosphatases work and interact, we can better understand how cells grow and divide. This knowledge is crucial for understanding many health conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this work may seek individuals with conditions related to cell division.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not directly benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of how cells control their division could lead to new ways to address diseases where cell division goes wrong, such as cancer.
How similar studies have performed: While much is known about "on switch" signals, this project addresses significant gaps in our knowledge about the "off switch" signals, making its approach to phosphatases quite novel.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Kettenbach, Arminja Nadine — Dartmouth College
- Study coordinator: Kettenbach, Arminja Nadine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.