Understanding how cells control the size of their organelles
Design Principles of Size-Control of Organelles Growing in a Shared Pool of their Building Blocks
This study is looking at how cells keep their tiny parts, called organelles, the right size, which is important for their health, and it could help people with neurodegenerative disorders by improving our understanding of how these processes might go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rochester Institute of Technology NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10893019 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells regulate the size of organelles, which are essential components of cellular function. By utilizing mathematical modeling and simulations, the study aims to uncover how organelles maintain their structure despite fluctuations in their building blocks. The research focuses on identifying key proteins and feedback mechanisms that influence organelle size, which could lead to more efficient experimental approaches in biochemistry. Patients with neurodegenerative disorders may benefit from insights gained about cellular processes that could be disrupted in their conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals diagnosed with Alzheimer's disease or other neurodegenerative disorders.
Not a fit: Patients with acute or non-degenerative conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and potentially treating neurodegenerative diseases like Alzheimer's and ALS.
How similar studies have performed: Previous research using mathematical modeling in cellular biology has shown promise, indicating that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Rochester Institute of Technology — Rochester, United States (Active)
Researchers
- Principal investigator: Mohapatra, Lishibanya — Rochester Institute of Technology
- Study coordinator: Mohapatra, Lishibanya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.