Understanding how cells control protein production
Mechanisms of eIF3-mediated translation regulation
This project explores how cells precisely manage making proteins, which is vital for healthy growth and preventing diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11136926 on NIH RePORTER |
What this research studies
Our cells need to carefully control which proteins they make and when, a process called mRNA translation, to grow and develop correctly. When this control goes wrong, it can contribute to diseases such as cancer. This work focuses on a key cellular component called eIF3, which helps start the protein-making process. We want to learn how eIF3 specifically directs the creation of certain proteins, beyond its general role, to influence cell behavior. Understanding these fundamental mechanisms could reveal new ways to target diseases where protein production is disrupted.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to understand basic cellular processes relevant to anyone affected by cancers.
Not a fit: Patients seeking immediate new treatments or clinical trial participation would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could uncover new basic insights into cell growth and differentiation, potentially leading to new targets for cancer therapies.
How similar studies have performed: This project builds upon recent discoveries about eIF3's specialized roles, exploring novel aspects of its function.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Lee, Amy Si-Ying — Dana-Farber Cancer Inst
- Study coordinator: Lee, Amy Si-Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.