Understanding how cells control metabolism
Official title: Identifying and characterizing metabolic control mechanisms
Funded at New York University School of Medicine · NIH-11011964 · Data updated 2026-11-12
This study is looking at how cells detect and react to the nutrients they need, especially focusing on certain proteins that help with this process, and it aims to learn more about how these proteins influence important body functions, which could help us understand diseases better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $466,125 |
| NIH project number | 1R35GM156605-01 |
| Project ID | NIH-11011964 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or degenerative neurological diseases, such as Friedreich's Ataxia.
✕Less likely to help
Patients with unrelated metabolic conditions or those not affected by degenerative diseases may not benefit from this research.
What this research studies
This research investigates the mechanisms that cells use to sense and respond to nutrient levels, focusing on specific proteins known as metabolite sensors. By creating cell and mouse models with altered sensing mechanisms, the research aims to uncover how these sensors affect metabolic processes, particularly in relation to pyrimidine biosynthesis and iron metabolism. The study will involve detailed analysis of engineered proteins to understand their regulatory roles in metabolism, which could lead to insights into various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing metabolic disorders and degenerative diseases.
How similar studies have gone: Previous research has shown success in understanding metabolic control mechanisms, indicating that this approach has potential for significant findings.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Possemato, Richard Lewis — New York University School of Medicine
- Study coordinator: Possemato, Richard Lewis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.