Understanding how cells control gene activity in diseases like cancer
Post-transcriptional control of gene expression by the mTORC1 signaling pathway
This work explores how a key cellular pathway called mTORC1 helps cells decide which proteins to make, which is important for understanding diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11163210 on NIH RePORTER |
What this research studies
Our cells constantly make proteins from genetic instructions, a process that is carefully controlled by various signals. This project focuses on the mTORC1 pathway, a master regulator that senses nutrients and tells cells to grow. When this pathway doesn't work correctly, it can lead to serious health problems, including different types of cancers and neurological conditions. We are learning how mTORC1 influences which proteins are made and how stable they are, especially focusing on hundreds of specific genetic messages. Our goal is to uncover the features that determine how these messages are read and translated into proteins, which could reveal new ways to target diseases.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit those affected by cancers and other diseases linked to cell growth and gene regulation.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of how diseases like cancer develop and potentially identify new targets for future treatments.
How similar studies have performed: While the mTORC1 pathway is a known area of research, this project explores novel aspects of its control over gene expression, building on prior successes in understanding cellular growth mechanisms.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Thoreen, Carson Cornell — Yale University
- Study coordinator: Thoreen, Carson Cornell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.