Understanding how cells control gene activity
Mapping and modeling transcription factor networks
This study is exploring how tiny sensors in cells help control proteins that manage gene activity, using yeast to figure out how these systems work, with the hope of finding ways to improve health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11052483 on NIH RePORTER |
What this research studies
This research investigates how cells use molecular sensors and signaling pathways to control the activity of transcription factors, which are proteins that regulate gene expression. By developing computational and molecular techniques, the research aims to map the networks of these transcription factors and observe how they respond to various signals. The ultimate goal is to rewire these control circuits to improve human health. The study primarily uses yeast as a model organism due to its simple genome and extensive experimental resources.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic disorders or diseases that could be treated by targeting specific gene expressions.
Not a fit: Patients with conditions unrelated to gene regulation or those who do not have a genetic component to their disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may improve treatments for various diseases.
How similar studies have performed: Other research has shown success in using similar approaches to map gene regulatory networks, indicating that this methodology is promising.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Brent, Michael R — Washington University
- Study coordinator: Brent, Michael R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.