Understanding how cells control DNA replication to maintain genome stability
Cell Cycle Dynamics that Ensure Genome Maintenance
This study is looking at how our cells make copies of their DNA, which is really important for keeping our genes stable and healthy, and it could help us find better ways to treat cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10876476 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate the cell division cycle, focusing on how DNA replication is initiated and maintained. It aims to uncover the processes that ensure the proper licensing of DNA replication origins, which is crucial for preventing genome instability. By studying how these processes are affected during different phases of the cell cycle and in various cellular environments, the research seeks to provide insights that could lead to better understanding and treatment of conditions like cancer. The methodology involves examining the roles of specific proteins and complexes involved in DNA replication and their regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with cancers, particularly those related to genomic instability.
Not a fit: Patients with conditions unrelated to cell cycle regulation or DNA replication may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers by enhancing our understanding of cell proliferation control.
How similar studies have performed: Other research has shown success in understanding DNA replication mechanisms, indicating that this approach has potential for significant advancements.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Cook, Jeanette Gowen — Univ of North Carolina Chapel Hill
- Study coordinator: Cook, Jeanette Gowen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.