Understanding how cells control division to prevent cancer
Spindle Assembly Checkpoint Silencing
This study is looking at how cells make sure they divide correctly, which is really important for preventing cancer, and it could help us find new ways to treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10919756 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate the cell cycle, particularly focusing on the spindle assembly checkpoint (SAC) which ensures proper chromosome segregation during cell division. By examining how the Anaphase-Promoting Complex/Cyclosome (APC/C) is activated and how it interacts with various proteins, the research aims to uncover the intricate processes that prevent uncontrolled cell division, a hallmark of cancer. The study employs advanced techniques such as cryo-electron microscopy to visualize these molecular interactions in detail. Patients may benefit from insights gained into cancer development and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for cancers related to cell cycle abnormalities or those currently undergoing treatment for such cancers.
Not a fit: Patients with cancers not related to cell cycle dysregulation may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with cell cycle dysregulation.
How similar studies have performed: Previous research has shown success in understanding cell cycle regulation, but this specific approach focusing on the APC/C and SAC is relatively novel.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Brown, Nicholas Gene — Univ of North Carolina Chapel Hill
- Study coordinator: Brown, Nicholas Gene
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.