Understanding how cells complete DNA replication
Eukaryotic Completion of DNA Replication
['FUNDING_OTHER'] · PORTLAND STATE UNIVERSITY · NIH-10906182
This study looks at how baker's yeast cells copy their DNA, which is important for keeping our genes healthy, and the findings could help us understand more about cancer and other diseases that affect people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PORTLAND STATE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-10906182 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which cells recognize and complete DNA replication, focusing on the model organism Saccharomyces cerevisiae (baker's yeast). The study aims to identify the enzymatic pathways involved in this process, which is crucial for maintaining genomic stability. By examining the similarities between bacterial and eukaryotic systems, the research seeks to uncover fundamental biological processes that could have implications for understanding cancer and other diseases. Patients may benefit from insights gained about DNA replication and its role in cell health and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic predispositions to cancer, particularly those with mutations in the BRCA2 gene.
Not a fit: Patients with conditions unrelated to DNA replication or genomic stability may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genomic stability, which may enhance cancer treatment strategies.
How similar studies have performed: Other research has shown success in understanding DNA replication mechanisms in bacteria, but this specific approach in eukaryotic cells is relatively novel.
Where this research is happening
PORTLAND, UNITED STATES
- PORTLAND STATE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COURCELLE, JUSTIN — PORTLAND STATE UNIVERSITY
- Study coordinator: COURCELLE, JUSTIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer 2 Gene, Breast Cancer Type 2 Susceptibility Gene