Understanding how cells complete DNA replication
Official title: Eukaryotic Completion of DNA Replication
Funded at Portland State University · NIH-10906182 · Data updated 2026-11-12
This study looks at how baker's yeast cells copy their DNA, which is important for keeping our genes healthy, and the findings could help us understand more about cancer and other diseases that affect people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland State University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $147,045 |
| NIH project number | 5R16GM145543-03 |
| Project ID | NIH-10906182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic predispositions to cancer, particularly those with mutations in the BRCA2 gene.
✕Less likely to help
Patients with conditions unrelated to DNA replication or genomic stability may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which cells recognize and complete DNA replication, focusing on the model organism Saccharomyces cerevisiae (baker's yeast). The study aims to identify the enzymatic pathways involved in this process, which is crucial for maintaining genomic stability. By examining the similarities between bacterial and eukaryotic systems, the research seeks to uncover fundamental biological processes that could have implications for understanding cancer and other diseases. Patients may benefit from insights gained about DNA replication and its role in cell health and disease.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genomic stability, which may enhance cancer treatment strategies.
How similar studies have gone: Other research has shown success in understanding DNA replication mechanisms in bacteria, but this specific approach in eukaryotic cells is relatively novel.
Where this research is happening
-
Portland State University
Portland, United States Active
Researchers
- Principal investigator: Courcelle, Justin — Portland State University
- Study coordinator: Courcelle, Justin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.