Understanding how cells compete to eliminate abnormal cells in tissues
Official title: Cell Competition in Development and Homeostasis
Funded at University of California-Irvine · NIH-10982137 · Data updated 2026-11-12
This study is looking at how our body's cells work together to keep us healthy by getting rid of damaged cells, especially those with the wrong number of chromosomes, which can lead to aging and cancer; it's using fruit flies to learn more about the genes involved in this process, hoping to find new ways to help treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $408,913 |
| NIH project number | 9R01CA284362-10A1 |
| Project ID | NIH-10982137 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to aneuploidy or cancer, as well as those interested in the biological mechanisms of aging.
✕Less likely to help
Patients with no genetic abnormalities or those not affected by cancer or aging-related conditions may not benefit from this research.
What this research studies
This research investigates the process of cell competition, where genetically different cells are removed from tissues to maintain healthy cellular function. It focuses on how certain genes, particularly those encoding ribosomal proteins, can detect and eliminate aneuploid cells—cells with abnormal chromosome numbers that contribute to aging and cancer. Using fruit flies as a model, the study will explore the genetic mechanisms involved in this process and how they relate to tumor formation and genome protection. By examining these cellular interactions, the research aims to uncover insights that could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that target and eliminate abnormal cells, potentially reducing the risk of cancer and improving health during aging.
How similar studies have gone: Previous research has shown promising results in understanding cell competition and its implications for cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Baker, Nicholas E — University of California-Irvine
- Study coordinator: Baker, Nicholas E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.