Understanding how cells communicate with each other to improve disease insights
Official title: Leveraging multiple Common Fund datasets to rank cell-cell interactions for faster hypothesis generation
Funded at Dartmouth College · NIH-10775907 · Data updated 2026-11-12
This study is looking at how cells in our body communicate with each other to keep tissues healthy, and it's for anyone interested in understanding how these interactions might change when we get sick or face environmental challenges.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | September 20, 2023 |
| Project end | September 19, 2025 |
| Funding year | 2023 |
| Award (this year) | $237,411 |
| NIH project number | 1R03OD036489-01 |
| Project ID | NIH-10775907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting epithelial barrier tissues, such as those with intestinal disorders or skin diseases.
✕Less likely to help
Patients with conditions unrelated to cell-cell interactions or those not involving epithelial barrier tissues may not benefit from this research.
What this research studies
This research focuses on cell-cell interactions, which are essential for maintaining healthy tissue functions. By utilizing existing datasets, the project aims to identify and rank these interactions to better understand how they contribute to tissue health or disease. The approach involves analyzing single-cell transcriptomic data to predict interactions between cells and developing a computational tool to prioritize these interactions for further experimental validation. This could lead to new insights into how different tissues respond to diseases and environmental challenges.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular communication, leading to improved strategies for treating diseases related to tissue dysfunction.
How similar studies have gone: Previous research has successfully utilized computational methods to analyze cell interactions, indicating that this approach has potential for meaningful insights.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Goods, Brittany Anne — Dartmouth College
- Study coordinator: Goods, Brittany Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.