Understanding how cells communicate through tiny vesicles called exosomes
Molecular Basis and Regulatory Mechanisms of Exosome Secretion
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11076293
This study is looking at tiny bubbles called exosomes that cells release, to understand how they work and how they might affect diseases like cancer, so we can learn more about how these bubbles influence cell behavior and disease progression.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11076293 on ClinicalTrials.gov |
What this research studies
This research investigates the role of exosomes, which are small vesicles secreted by cells that carry important signaling molecules. By studying how these exosomes are formed and how they communicate with other cells, the research aims to uncover the underlying mechanisms that regulate their release and function. This could provide insights into various diseases, including cancer, by understanding how exosomes influence cell behavior and contribute to disease progression. The research employs advanced cell biology techniques to explore the biogenesis and transport of exosomes within cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancer or those at risk of developing cancer, as well as individuals with conditions related to cell communication.
Not a fit: Patients with non-cancerous conditions unrelated to cell signaling or exosome function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer diagnosis and treatment by targeting exosome communication pathways.
How similar studies have performed: Other research has shown promising results in understanding exosome functions in various diseases, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUO, WEI — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: GUO, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy, Cancer Biology, cancer diagnosis, cancer microenvironment, cancer progression