Understanding how cells communicate through tiny channels
Dynamic Mechanisms of Membrane Channel Gating by CryoEM
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11163451
This project aims to uncover the secrets of how tiny channels in our cells, called gap junctions, help different parts of our body, like the heart and brain, work together.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11163451 on ClinicalTrials.gov |
What this research studies
Our bodies rely on cells talking to each other, and these conversations happen through special channels in cell membranes. This research uses advanced imaging, called electron cryo-microscopy (CryoEM), along with computer models and other lab techniques, to see these channels up close. We want to learn exactly how these channels control the flow of information between cells, how they respond to signals from the body or medicines, and how their structure is influenced by their surroundings. By understanding these fundamental processes, we hope to shed light on how they contribute to various health conditions, including cancers and heart problems.
Who could benefit from this research
Good fit: This foundational laboratory research does not involve direct patient participation, but future clinical applications could benefit patients with conditions related to cell communication, such as certain cancers or heart disorders.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how diseases like cancer and heart rhythm problems develop, potentially guiding the creation of new treatments.
How similar studies have performed: This project leverages recent breakthroughs in high-resolution CryoEM technology, which has shown great success in revealing the detailed structures of complex biological molecules.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REICHOW, STEPHEN LOEN — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: REICHOW, STEPHEN LOEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers