Understanding how cells communicate through signaling at their membranes
Reconstructing and deconstructing intracellular signaling at the membrane-cytosol interface
This study is exploring how cells communicate and respond to signals, which is important for understanding diseases, by using a new method that mimics how these processes happen in real cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11253331 on NIH RePORTER |
What this research studies
This research investigates the complex biochemical interactions that occur at the cell membrane, which are crucial for generating specific cellular responses. By developing a novel approach that combines cell extracts with model membrane systems, the research aims to recreate the intricate signaling networks found in living cells. This method allows for a better understanding of how signals are processed and regulated, which is essential for addressing defects linked to various diseases. The project focuses on the receptor tyrosine kinase pathway, aiming to clarify the mechanisms of signal amplification and attenuation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular signaling abnormalities, particularly those with specific types of cancer.
Not a fit: Patients with conditions unrelated to cellular signaling or those who do not have any signaling pathway defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases caused by signaling defects, including various cancers.
How similar studies have performed: Previous research has shown promise in understanding cellular signaling through similar biochemical approaches, indicating potential for success in this innovative method.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Huang, Yuan-Chi — Johns Hopkins University
- Study coordinator: Huang, Yuan-Chi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.