Understanding how cells communicate in COPD
Official title: Local cellular communication networks in COPD endotypes
Funded at Yale University · NIH-11067867 · Data updated 2026-11-12
This study is looking at how cells in the lungs of people with Chronic Obstructive Pulmonary Disease (COPD) communicate with each other, hoping to find new ways to treat the condition by analyzing lung tissue samples from participants.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $125,625 |
| NIH project number | 5R21HL173512-02 |
| Project ID | NIH-11067867 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Chronic Obstructive Pulmonary Disease (COPD), particularly those with varying clinical presentations.
✕Less likely to help
Patients without a diagnosis of COPD or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research investigates the communication networks between cells in patients with Chronic Obstructive Pulmonary Disease (COPD). By utilizing advanced techniques like single-cell sequencing and spatial transcriptomics, the study aims to identify abnormal cell populations and their interactions within the lung tissue. The goal is to uncover the mechanisms behind the diverse manifestations of COPD, which may lead to new therapeutic strategies tailored to individual patients. Participants may contribute to a better understanding of their condition through the analysis of their lung tissue samples.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment options for patients with COPD, improving their quality of life.
How similar studies have gone: Previous research has shown promise in understanding cell communication in other diseases, suggesting that this approach could yield valuable insights in COPD as well.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Sauler, Maor — Yale University
- Study coordinator: Sauler, Maor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.