Understanding how cells communicate in breast cancer environments
Identifying intercellular circuits driving cell phenotypes within a niche
This study is looking at how different types of cells in breast cancer tissues talk to each other and how that affects the cancer's growth, with the hope that understanding these interactions can lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10684299 on NIH RePORTER |
What this research studies
This research investigates the complex communication networks between different cell types within tissues, particularly in the context of breast cancer. By combining advanced techniques like single cell sequencing and live cell imaging, the study aims to identify how these intercellular circuits influence cell behavior and disease progression. Patients may benefit from insights into how their cancer cells interact with surrounding cells, potentially leading to new therapeutic strategies. The research focuses on understanding the role of immune cells and fibroblasts in the metastatic niche, which is crucial for cancer spread.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those with metastatic disease.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with breast cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the communication pathways between cancer cells and their environment, improving patient outcomes.
How similar studies have performed: Other research has shown promise in understanding cell communication in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Shea, Lonnie D — University of Michigan at Ann Arbor
- Study coordinator: Shea, Lonnie D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.