Understanding how cells communicate during the development of the sense of smell
Resolving Spatiotemporally-Specific Multicellular Dynamics In Vivo During Olfactory Neurogenesis
This study looks at how different types of cells work together to help zebrafish develop their sense of smell, which could help us understand how problems in this process might lead to brain issues in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10834141 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between different cell types during the development of the olfactory system in zebrafish. By using advanced imaging techniques, the study aims to observe how specific signaling pathways, like Notch and Wnt, influence the migration and differentiation of stem cells into sensory neurons. Patients may benefit from insights gained about how disruptions in these processes could lead to neurological defects. The research employs innovative methods to manipulate and analyze cell behavior in real-time, providing a detailed understanding of neurogenesis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital neurological disorders or birth defects affecting the olfactory system.
Not a fit: Patients with neurological conditions unrelated to olfactory development may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurological defects related to olfactory development.
How similar studies have performed: Previous studies have shown success in understanding cell signaling in other developmental contexts, suggesting potential for breakthroughs in this area as well.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Saxena, Ankur — University of Alabama at Birmingham
- Study coordinator: Saxena, Ankur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.