Understanding how cells communicate and respond to their environment
Single Cell Analysis of MAPK Signaling Dynamics in Multicellularity
This study is exploring how cells communicate and react to their surroundings by looking closely at a specific signaling pathway, which could help us understand how cells work together in the body, using special tools and live animal models.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11009294 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells amplify signaling events to effectively respond to their environment, focusing on the Mitogen Activated Protein Kinase (MAPK) pathway. By utilizing advanced biosensors and automated imaging technologies, the study aims to quantify signaling activities in thousands of individual cells within multicellular systems. The research also employs transgenic mouse models to observe these signaling events in live tissues and embryos, providing insights into how cells coordinate their behavior in response to various stimuli.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve disrupted cell signaling or communication, such as cancer or developmental disorders.
Not a fit: Patients with conditions unrelated to cell signaling dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cell signaling, potentially informing treatments for diseases related to cell communication and behavior.
How similar studies have performed: Other research has shown success in understanding cell signaling dynamics, making this approach both relevant and promising.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Regot, Sergi — Johns Hopkins University
- Study coordinator: Regot, Sergi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.