Understanding how cells communicate and move during tissue development
Mechanosensitive mechanisms regulating cellular coordination during tissue morphogenesis and patterning
This study is looking at how cells in our body feel and respond to physical forces, helping them work together to form healthy tissues, which is important for keeping our organs functioning well, and it could help us understand problems like atrial fibrillation when things go wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11141483 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells sense mechanical signals and coordinate their movements during the development of tissues. It focuses on how specific proteins that respond to mechanical forces influence the transfer of electrical signals and other important molecules between cells. By studying these processes, the research aims to uncover how cells communicate and work together in a healthy tissue environment, which is crucial for maintaining proper function in various organs. The findings could provide insights into how disruptions in these mechanisms contribute to diseases such as atrial fibrillation and other conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular communication issues, such as atrial fibrillation or other cardiac arrhythmias.
Not a fit: Patients with conditions unrelated to mechanosensitive mechanisms or those who do not have any cellular communication disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to impaired cellular communication and movement.
How similar studies have performed: Other research has shown promising results in understanding mechanosensitive mechanisms, indicating that this approach has potential for significant advancements in the field.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Stratman, Amber Nicole — Washington University
- Study coordinator: Stratman, Amber Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.