Understanding how cells communicate and join together
Conserved mechanisms of ciliary signaling and cell-cell fusion
This project explores how cells talk to each other and fuse, using a tiny green alga to uncover basic processes that are important for human health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project ID | NIH-11124940 on NIH RePORTER |
What this research studies
Researchers are studying how cells communicate and merge, using a simple green alga called Chlamydomonas as a model. They are focusing on how tiny hair-like structures called cilia on these cells stick together and send signals inside, leading to cell fusion. This process involves a key signaling molecule called cAMP and a newly discovered protein kinase, GSPK. Understanding these fundamental steps in algae can shed light on similar, but poorly understood, processes in human cells.
Who could benefit from this research
Good fit: This basic science project does not involve direct patient participation, but it is relevant for those interested in the fundamental biology underlying human diseases involving cilia or cell fusion.
Not a fit: Patients seeking immediate clinical trials or direct treatment options would not find direct benefit from this foundational research.
Why it matters
Potential benefit: If successful, this foundational knowledge could help us better understand diseases where cell communication or fusion goes wrong, such as certain developmental disorders or infertility.
How similar studies have performed: This project builds on existing knowledge of ciliary signaling but aims to uncover previously unrecognized steps and mechanisms that are still poorly understood.
Where this research is happening
College Park, United States
- Univ of Maryland, College Park — College Park, United States (Active)
Researchers
- Principal investigator: Snell, William J — Univ of Maryland, College Park
- Study coordinator: Snell, William J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.