Understanding how cells communicate and change
Decoding the logic of cellular signaling through the integration of dynamic, single-cell and multiplexed methods
['FUNDING_OTHER'] · UNIVERSITY OF VIRGINIA · NIH-11161374
This project aims to understand how individual cells respond to signals and change their behavior, which is important for many health conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11161374 on ClinicalTrials.gov |
What this research studies
Our bodies are made of many cells, and each cell can respond differently to signals, even if they are genetically identical. This difference comes from how cells process information based on their unique internal "state," like their epigenome and gene activity. This project seeks to uncover how these cell states are formed, how they become diverse or flexible, and how they combine with incoming signals to make decisions. By focusing on a key network called AP-1, we hope to learn how cells link external messages to changes in their identity and function.
Who could benefit from this research
Good fit: While this is a basic science project, future clinical applications may benefit patients with conditions related to abnormal cell signaling and cell state changes.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not directly benefit from this foundational research.
Why it matters
Potential benefit: A deeper understanding of cell communication could lead to new ways to treat diseases where cell signaling goes wrong, such as cancer or autoimmune disorders.
How similar studies have performed: This project builds upon recent findings by the researchers regarding the AP-1 network, suggesting a novel approach within an established field of cell signaling.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FALLAHI-SICHANI, MOHAMMAD — UNIVERSITY OF VIRGINIA
- Study coordinator: FALLAHI-SICHANI, MOHAMMAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.