Understanding how cells communicate and adapt during tissue development
Principles of Mechanochemical Signal Integration Underlying Developmental Robustness
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-10932878
This study is looking at how cells in developing tissues work together and respond to their surroundings, which could help us create better artificial tissues that act more like natural ones.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10932878 on ClinicalTrials.gov |
What this research studies
This research investigates the cellular mechanisms that allow embryonic tissues to develop consistently despite environmental changes. By focusing on how cells integrate both biochemical and mechanical signals, the project aims to uncover how cells can sense their surroundings and make decisions that ensure proper tissue formation. Utilizing advanced techniques such as live imaging and computational modeling, the research will explore how cells interact with each other and their environment to maintain robust tissue patterns. This could lead to improved methods for creating artificial tissues that better mimic natural development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with congenital abnormalities or those interested in advancements in tissue engineering.
Not a fit: Patients with fully developed tissues and no history of congenital defects may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in tissue engineering and regenerative medicine, improving treatments for congenital defects and other tissue-related disorders.
How similar studies have performed: Other research has shown promise in understanding cellular communication and tissue development, but this approach of integrating mechanical and biochemical signals is relatively novel.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSAI, TONY YU-CHEN — WASHINGTON UNIVERSITY
- Study coordinator: TSAI, TONY YU-CHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers