Understanding how cells clear dead cells to promote healing
Efferocytosis meets endocytosis
This study is looking at how certain cells in your body help clean up dead cells to keep your tissues healthy, and it aims to understand how this process works so we can better tackle issues like chronic inflammation and related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10892094 on NIH RePORTER |
What this research studies
This research investigates the process of efferocytosis, where cells called efferocytes clear away dead cells to maintain tissue health. When this process fails, it can lead to chronic inflammation and diseases. The study aims to uncover the mechanisms behind how efferocytes degrade dead cells and utilize their components, particularly focusing on the role of specialized molecules that help resolve inflammation. By exploring these processes, the research seeks to enhance our understanding of tissue repair and inflammation resolution.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory conditions or diseases related to defective cell clearance.
Not a fit: Patients with acute injuries or conditions unrelated to inflammation or cell clearance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic inflammatory diseases by improving tissue repair mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding efferocytosis and its role in inflammation, indicating that this approach has potential for significant advancements.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Cai, Bishuang — Icahn School of Medicine at Mount Sinai
- Study coordinator: Cai, Bishuang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.