Understanding how cells clean themselves to slow aging
Hormetic regulation of autophagy in aging
['FUNDING_R01'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-11128694
This research explores how a cell cleaning process called autophagy, which naturally slows down as we age, can be boosted to help us stay healthier longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11128694 on ClinicalTrials.gov |
What this research studies
Our bodies' cells have a natural recycling system called autophagy that cleans out damaged parts, but this system often becomes less active as we get older. This project looks at how short periods of stress, like a brief heat exposure, can actually kickstart this cleaning process in cells. We are working to understand exactly when and where this cellular cleanup is most important for long-term health benefits. The goal is to uncover the specific genes and pathways involved in keeping our cells healthy and resilient against aging.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future applications could benefit individuals interested in healthy aging and preventing age-related conditions.
Not a fit: Patients seeking immediate clinical treatments or direct participation opportunities will not find them in this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to maintain cellular health, potentially slowing down age-related decline and preventing diseases.
How similar studies have performed: The concept of hormesis and the role of autophagy in aging are well-established areas of research, with previous studies showing links between cellular stress responses and longevity.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUMSTA, CAROLINE — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: KUMSTA, CAROLINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.