Understanding how cells change their state during development and disease
Official title: Mechanisms of RNA turnover during the epithelial-mesenchymal transition
Funded at University of California, San Francisco · NIH-11083135 · Data updated 2026-11-12
This study is looking at how certain cells change their behavior, which is important for healing and development, especially in conditions like cancer and fibrosis, to help us understand how to better manage these health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $403,750 |
| NIH project number | 5R35GM150763-03 |
| Project ID | NIH-11083135 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal cell transitions, such as certain types of cancer or fibrosis.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve cellular transitions may not benefit from this research.
What this research studies
This research investigates how cells alter their gene expression to transition between different states, which is crucial for processes like development, wound healing, and regeneration. The focus is on the epithelial-mesenchymal transition (EMT), a key cellular change involved in various diseases, including cancer and fibrosis. By studying neural crest cells as a model, the research aims to uncover the mechanisms of RNA turnover that influence these transitions, particularly the role of post-transcriptional regulation. This could lead to a better understanding of how to control these processes in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases characterized by abnormal cell state transitions, such as cancer.
How similar studies have gone: Previous research has shown success in understanding cellular transitions, but this specific focus on RNA turnover during EMT is relatively novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Hutchins, Erica — University of California, San Francisco
- Study coordinator: Hutchins, Erica
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.