Understanding how cells change their identity through DNA repair
Overcoming epigenetic barriers to somatic cell reprogramming by the XPC DNA repair complex
This project aims to discover how certain proteins help cells change their type by adjusting their DNA, which could lead to new ways to treat diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11136408 on NIH RePORTER |
What this research studies
Our bodies are made of many different cell types, and sometimes we need cells to change their identity, like for healing or development. This project looks at how a special protein, TDG, helps cells reprogram by changing marks on their DNA. We're particularly interested in another protein, XPC, which seems to guide TDG to the right places in the DNA. By understanding how XPC and TDG work together, we hope to learn more about how cells can transform from one type to another.
Who could benefit from this research
Good fit: This foundational laboratory research does not directly involve patients, but future applications could benefit individuals with conditions related to cell development, regeneration, or DNA repair.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge for developing new treatments that involve guiding cells to change their identity, potentially for regenerative medicine or correcting disease states.
How similar studies have performed: Previous work has identified XPC as an activator of TDG-dependent DNA changes, suggesting a promising direction for this deeper exploration.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Fong, Yick Wah — Brigham and Women's Hospital
- Study coordinator: Fong, Yick Wah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.