Understanding how cells change states in various diseases
Official title: Landscapes for Cell State Transition Leveraging by Single-Cell Multi-Omics
Funded at Methodist Hospital Research Institute · NIH-10914218 · Data updated 2026-11-12
This study is working on new ways to understand how cells change from one type to another, which is important for things like organ growth and diseases such as Alzheimer's, diabetes, and heart problems, so we can find better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $403,739 |
| NIH project number | 5R35GM150460-02 |
| Project ID | NIH-10914218 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Alzheimer's disease, type 2 diabetes, or other conditions related to cell fate transitions.
✕Less likely to help
Patients with conditions unrelated to cell fate transitions or those not affected by the diseases being studied may not benefit from this research.
What this research studies
This research aims to develop new mathematical methods and tools to understand how cells transition between different states, which is crucial in organ development and disease progression. By analyzing large datasets from single-cell atlases, the project seeks to uncover the mechanisms behind cell fate changes that can lead to conditions like Alzheimer's disease, diabetes, and heart failure. The approach involves creating computational methods to automatically identify and annotate these transitions, providing insights that could lead to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases related to cell fate dysregulation, such as Alzheimer's and diabetes.
How similar studies have gone: Other research has shown promise in using single-cell atlases to understand cellular dynamics, making this approach a continuation of successful methodologies.
Where this research is happening
-
Methodist Hospital Research Institute
Houston, United States Active
Researchers
- Principal investigator: Wang, Guangyu — Methodist Hospital Research Institute
- Study coordinator: Wang, Guangyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.