Understanding how cells change states in various diseases
Landscapes for Cell State Transition Leveraging by Single-Cell Multi-Omics
This study is working on new ways to understand how cells change from one type to another, which is important for things like organ growth and diseases such as Alzheimer's, diabetes, and heart problems, so we can find better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10914218 on NIH RePORTER |
What this research studies
This research aims to develop new mathematical methods and tools to understand how cells transition between different states, which is crucial in organ development and disease progression. By analyzing large datasets from single-cell atlases, the project seeks to uncover the mechanisms behind cell fate changes that can lead to conditions like Alzheimer's disease, diabetes, and heart failure. The approach involves creating computational methods to automatically identify and annotate these transitions, providing insights that could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Alzheimer's disease, type 2 diabetes, or other conditions related to cell fate transitions.
Not a fit: Patients with conditions unrelated to cell fate transitions or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases related to cell fate dysregulation, such as Alzheimer's and diabetes.
How similar studies have performed: Other research has shown promise in using single-cell atlases to understand cellular dynamics, making this approach a continuation of successful methodologies.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Wang, Guangyu — Methodist Hospital Research Institute
- Study coordinator: Wang, Guangyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.