Understanding how cells change shape during embryo development
Regulation of dynamic actin networks during epithelial morphogenesis
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11077276
This study looks at how cells in a tiny worm called C. elegans work together and change shape during development, which is important for making healthy tissues and organs, and it aims to understand how these processes can help prevent birth defects and cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11077276 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic processes that allow cells in an embryo to reshape and reorganize during development, which is crucial for forming tissues and organs. Using the model organism C. elegans, the study focuses on the interactions between proteins that help cells stick together and how these interactions are influenced by mechanical forces. The researchers will employ advanced techniques in genetics, biophysics, and live imaging to explore how these cellular mechanisms contribute to normal development and the prevention of birth defects and cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of birth defects or cancers related to epithelial tissue development.
Not a fit: Patients with conditions unrelated to epithelial morphogenesis or those who are not affected by birth defects or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing birth defects and treating cancers by understanding the fundamental processes of cell behavior.
How similar studies have performed: Previous research has shown promising results in understanding cell behavior and development using similar model organisms, indicating that this approach has potential for success.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARDIN, JEFFREY D — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: HARDIN, JEFFREY D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.