Understanding how cells change shape during division
Mechanisms of cell shape change in cytokinesis
This study is looking at how cells split into two and what helps them change shape during this process, which is important for keeping our genes safe and preventing diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11012393 on NIH RePORTER |
What this research studies
This research investigates the process of cytokinesis, which is how a single cell divides into two distinct daughter cells. It focuses on the mechanisms that control cell shape changes during this division, particularly the role of cytoskeletal elements like actin filaments and myosin. By studying these processes, the research aims to uncover how cells maintain genome stability and how disruptions in this process can lead to diseases such as cancer. The approach includes examining cellular behaviors and signaling pathways that guide these shape changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal cell division or proliferation, such as certain cancers or blood disorders.
Not a fit: Patients with stable, non-proliferative conditions or those not affected by cell division abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing and treating diseases related to cell division, such as cancer.
How similar studies have performed: Other research has shown success in understanding cell division mechanisms, making this approach both relevant and promising.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Maddox, Amy Shaub — Univ of North Carolina Chapel Hill
- Study coordinator: Maddox, Amy Shaub
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.