Understanding how cells change shape during development
C. elegans Gastrulation: a Model for Understanding Apical Constriction Mechanisms
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11082458
This study looks at how certain cells change shape during development, which is important for forming structures in animals, and by using tiny worms called C. elegans, researchers hope to learn more about the causes of birth defects like spina bifida and anencephaly, ultimately aiming to improve ways to diagnose and prevent these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11082458 on ClinicalTrials.gov |
What this research studies
This research investigates the process of apical constriction, a critical change in cell shape that influences how animals develop, particularly in forming structures like the neural tube. By studying the model organism C. elegans, researchers aim to uncover the molecular mechanisms that drive this process and how it affects overall animal morphology. The research employs advanced techniques to analyze the forces and cellular architecture involved in these changes, with the goal of improving our understanding of congenital defects such as spina bifida and anencephaly. Insights gained could lead to better diagnostic and preventive strategies for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with a family history of neural tube defects or congenital abnormalities.
Not a fit: Patients with conditions unrelated to developmental biology or congenital defects may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of serious birth defects.
How similar studies have performed: Previous research has shown success in understanding cellular mechanisms in developmental biology, making this approach promising.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLDSTEIN, ROBERT P — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: GOLDSTEIN, ROBERT P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.