Understanding how cells change in the gastrointestinal tract after injury
A multi-modality approach to decode epithelial heterogeneity and function in metaplasia
This study is looking at how certain cells in the pancreas change when there's an injury, which could help us understand how the body heals and deals with inflammation, and it's aimed at anyone interested in learning more about pancreatic health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10873760 on NIH RePORTER |
What this research studies
This research investigates how certain cells in the gastrointestinal tract transform in response to injury, specifically focusing on a process called acinar to ductal metaplasia (ADM) in the pancreas. The researchers aim to develop new tools to study these changes and identify the different types of cells involved in ADM, as well as their roles in tissue repair and inflammation. By using advanced techniques like single-cell RNA sequencing and electron microscopy, they hope to uncover the physiological functions of these cells during the healing process.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who have experienced gastrointestinal injuries or related conditions.
Not a fit: Patients with stable gastrointestinal conditions that do not involve injury or metaplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of gastrointestinal injuries and diseases.
How similar studies have performed: Previous research has shown promising results in understanding cell transformation processes in other contexts, suggesting potential for success in this area as well.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Delgiorno, Kathleen Elizabeth — Vanderbilt University
- Study coordinator: Delgiorno, Kathleen Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.