Understanding how cells change during bone fracture healing
Cell Transitions during Bone Fracture Healing
This study is looking at how different cells in your body help heal bone fractures, especially how they change and adapt to the conditions around them, with the goal of finding ways to make healing faster and better for people with broken bones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10931443 on NIH RePORTER |
What this research studies
This research investigates the complex processes involved in bone fracture healing, focusing on how different types of cells transition and differentiate in response to mechanical environments. It explores the concept of 'paligenosis,' where fully differentiated cells can revert to a stem cell-like state, allowing them to become various cell types necessary for healing. The study aims to understand how these cell transitions occur, particularly how periosteal cells respond to mechanical stability or instability during the healing process. By examining these mechanisms, the research seeks to identify factors that could improve healing outcomes for patients with bone fractures.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced bone fractures.
Not a fit: Patients with non-bone-related injuries or conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and strategies for enhancing bone healing in patients with fractures.
How similar studies have performed: Other research has shown promising results in understanding cell differentiation and healing processes, suggesting that this approach could yield significant insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Marcucio, Ralph S — University of California, San Francisco
- Study coordinator: Marcucio, Ralph S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.