Understanding how cells change and respond to their environment
Official title: Defining a biophysical basis for cell types, cell states and cellular heterogeneity at single-cell resolution
Funded at Johns Hopkins University · NIH-11022628 · Data updated 2026-11-12
This study is looking at how cells change and adapt based on signals from inside and outside the body, which could help us understand diseases better and improve treatments, especially for things like aging and T-cell responses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $380,587 |
| NIH project number | 1R35GM157099-01 |
| Project ID | NIH-11022628 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions that involve cellular dysfunction or require innovative cell-based therapies.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve cellular changes may not benefit from this research.
What this research studies
This research investigates how cells adapt their identities based on internal signals and external cues, particularly in the context of health and disease. By utilizing advanced single-cell technologies, the project aims to profile individual cellular states and understand the molecular programs that drive cell behaviors. The research will focus on specific models, such as how epigenomic changes influence cell aging and how T-cell responses can be engineered for better therapeutic outcomes. Ultimately, this work seeks to provide insights into the mechanisms that define cellular identities and their implications for disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases by targeting specific cellular behaviors and identities.
How similar studies have gone: Other research has shown promise in understanding cellular behavior through single-cell technologies, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Phillip, Jude Marvin — Johns Hopkins University
- Study coordinator: Phillip, Jude Marvin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.