Understanding how cells avoid death and develop cancer
The role of autophagy in the escape from replicative crisis and tumorigenesis
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-10904946
This study is looking at how certain cells manage to survive when they're in trouble, which can lead to cancer, and it's especially interested in a process called autophagy that helps get rid of damaged cells; the goal is to find new ways to prevent and treat cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10904946 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which cells escape from a state of crisis that typically leads to cell death, which is a critical step in the development of cancer. The focus is on the role of autophagy, a cellular process that helps eliminate damaged cells, in preventing tumorigenesis. By utilizing advanced techniques such as CRISPR, the researchers aim to identify how disruptions in autophagy contribute to the survival of potentially cancerous cells. This work could provide insights into new therapeutic strategies for cancer prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those at high risk for developing malignancies due to genetic factors.
Not a fit: Patients who are not at risk for cancer or do not have any genetic predispositions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new approaches for preventing cancer by targeting the processes that allow cells to survive under conditions that typically lead to cell death.
How similar studies have performed: Other research has shown promising results in understanding the role of autophagy in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NASSOUR, JOE — UNIVERSITY OF COLORADO DENVER
- Study coordinator: NASSOUR, JOE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.