Understanding how cells attach chromosomes to the spindle during cell division
Molecular mechanisms controlling kinetochore-microtubule attachments during mitosis
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10835459
This study looks at how certain proteins help ensure that chromosomes are properly divided during cell division, which is important for understanding diseases that can happen when this process goes wrong, and it could help patients in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10835459 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that control how kinetochores, which are protein complexes on chromosomes, attach to microtubules during mitosis. By studying the dynamic interactions between kinetochores and microtubules, the research aims to uncover how these attachments contribute to the accurate segregation of chromosomes into daughter cells. The approach involves examining the roles of specific proteins, such as dynein and the Ndc80 complex, in facilitating these critical cellular processes. Patients may benefit from insights gained into the fundamental processes of cell division, which could have implications for understanding diseases related to chromosome missegregation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to aneuploidy or chromosome segregation errors.
Not a fit: Patients with conditions unrelated to chromosome segregation or those not experiencing aneuploidy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for conditions caused by chromosome missegregation, such as cancer.
How similar studies have performed: Other research has shown success in understanding similar mechanisms of chromosome segregation, indicating that this approach is grounded in established scientific inquiry.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VARMA, DILEEP — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: VARMA, DILEEP
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.