Understanding how cells attach chromosomes to the spindle during cell division
Molecular mechanisms controlling kinetochore-microtubule attachments during mitosis
This study is looking at how certain proteins help ensure that chromosomes are properly attached and separated during cell division, which is important for preventing diseases caused by mistakes in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10740846 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control how kinetochores, which are protein complexes on chromosomes, attach to microtubules during cell division. By studying the dynamic interactions between kinetochores and microtubules, the research aims to uncover how these attachments contribute to the accurate segregation of chromosomes into daughter cells. The approach involves examining the roles of specific proteins, such as dynein and the Ndc80 complex, in facilitating these attachments and ensuring proper chromosome alignment. This work could provide insights into the fundamental processes of cell division and the potential implications for diseases related to chromosome missegregation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to chromosome missegregation, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to chromosome segregation or those not experiencing aneuploidy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of chromosome segregation, which may help in developing therapies for conditions related to aneuploidy, such as cancer.
How similar studies have performed: Previous research has shown success in understanding similar mechanisms of chromosome segregation, indicating that this approach is built on established scientific principles.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Varma, Dileep — Northwestern University at Chicago
- Study coordinator: Varma, Dileep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.