Understanding how cells and molecules are arranged to affect disease
From pattern to function: eco-evolutionary representations of complex spatial structure for the new era of spatial biology
This research explores how the arrangement of cells and molecules in our bodies influences how diseases change and spread over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11181503 on NIH RePORTER |
What this research studies
We are using advanced imaging and computer models to look closely at how cells and molecules are organized in space. This helps us understand if certain arrangements make it easier or harder for new changes, like mutations in a disease, to spread. By connecting these models to detailed images, we aim to discover which spatial patterns might speed up or slow down the progression of diseases. This work helps us learn the fundamental rules of how biological systems evolve and adapt.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but it aims to understand general biological principles relevant to human health.
Not a fit: Patients seeking immediate clinical interventions or direct treatment options would not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this foundational work could lead to new ways of understanding how diseases evolve and spread, potentially informing future strategies for treatment or prevention.
How similar studies have performed: This project combines cutting-edge imaging analysis with theoretical evolutionary models in a novel way, building on established principles in both fields.
Where this research is happening
Pittsburgh, United States
- Carnegie-Mellon University — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Carja, Oana — Carnegie-Mellon University
- Study coordinator: Carja, Oana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.