Understanding how cells adapt to their environment over time
Official title: Multimodal Investigation of Cellular Adaptation Across Timescales
Funded at University of Chicago · NIH-10850195 · Data updated 2026-11-12
This study is exploring how cells, like yeast and cancer cells, adjust to changes in their environment, with the goal of finding new ways to treat diseases by understanding how they respond to stress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,380,568 |
| NIH project number | 1RM1GM153533-01 |
| Project ID | NIH-10850195 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to cellular stress responses, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve cellular adaptation may not receive benefits from this research.
What this research studies
This research investigates the mechanisms by which cells, including yeast and cancer cells, adapt to various environmental changes. By employing advanced techniques in biophysics and data science, the project aims to create a predictive model of cellular adaptation across different timescales. The research focuses on understanding stress-induced cellular responses and how these responses can be harnessed to develop new therapeutic strategies for diseases. Patients may benefit from insights that could lead to innovative treatments targeting maladaptive cellular states.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking therapies that effectively reprogram unhealthy cellular behaviors in various diseases.
How similar studies have gone: Other research has shown promise in understanding cellular adaptation, but this approach is innovative and aims to provide a comprehensive, multiscale perspective.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Pincus, David — University of Chicago
- Study coordinator: Pincus, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.