Understanding how cells adapt to stress through temperature changes
Function and Regulation of Stress-Induced Adaptive Condensates
This study looks at how our cells react to temperature changes, especially when we have a fever, by focusing on special clusters of proteins and RNA that help our immune system work better during stress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11037616 on NIH RePORTER |
What this research studies
This research investigates how cells respond to temperature changes, particularly focusing on the heat-shock response in eukaryotic cells. It explores the formation of biomolecular condensates, which are clusters of proteins and RNA that play crucial roles in cellular functions during stress. By using biochemical and cell biological methods, the research aims to identify how these condensates are formed and regulated, and how they contribute to the immune response during fever. The study also examines how temperature signals are sensed and translated into adaptive cellular responses, particularly in fungi and vertebrate immune cells.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions that involve stress responses at the cellular level, such as autoimmune diseases or infections.
Not a fit: Patients with conditions unrelated to cellular stress responses or those not involving immune system activation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how cells manage stress, potentially informing treatments for diseases related to cellular dysfunction.
How similar studies have performed: Other research has shown promising results in understanding cellular stress responses, but this approach focusing on adaptive condensates is relatively novel.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Drummond, David Allan — University of Chicago
- Study coordinator: Drummond, David Allan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.