Understanding how cells adapt to stress and nutrient changes in mitochondria
Official title: Coordination of PAR and Ub signaling in mitochondria
Funded at Boston University Medical Campus · NIH-11049039 · Data updated 2026-11-12
This study is looking at how cells adjust to changes in food and stress, especially in the tiny powerhouses called mitochondria, to understand how certain proteins might play a role in conditions like breast cancer and obesity, which could help improve health and treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $439,725 |
| NIH project number | 5R35GM149339-03 |
| Project ID | NIH-11049039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with metabolic disorders, obesity, or breast cancer.
✕Less likely to help
Patients with unrelated conditions or those not experiencing metabolic stress or cancer may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that help cells adapt to changes in nutrient availability and oxidative stress, particularly focusing on mitochondria, the energy-producing structures in cells. The team studies how certain proteins, like GPS2, regulate gene expression and protein function during these stress responses. By examining the role of ubiquitination, a process that modifies proteins, the research aims to uncover how these mechanisms contribute to conditions like breast cancer and obesity. Patients may benefit from insights gained about how these processes affect their health and treatment options.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating metabolic disorders and cancers by targeting mitochondrial function.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial stress responses, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Perissi, Valentina — Boston University Medical Campus
- Study coordinator: Perissi, Valentina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.