Understanding how cells adapt their growth cycles
Molecular basis of cell-cycle plasticity and robustness
This study is looking at how cancer cells can change their growth and division patterns when faced with different treatments, and it aims to find new ways to overcome drug resistance, which could help improve cancer therapies for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-10981127 on NIH RePORTER |
What this research studies
This research investigates the flexibility of the mammalian cell cycle, which is traditionally viewed as a fixed process. It explores how cells can adapt their growth and division pathways in response to different conditions, particularly in the context of cancer treatment. By examining the role of Cyclin-Dependent Kinases (CDKs) and their inhibitors, the research aims to uncover new strategies to combat drug resistance in cancer therapies. Patients may benefit from insights that could lead to more effective treatments for cancers that exploit these adaptive mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that are known to develop resistance to current therapies.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not exhibit cell-cycle plasticity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments that overcome drug resistance.
How similar studies have performed: Previous research has shown that understanding cell cycle dynamics can lead to significant advancements in cancer treatment, suggesting this approach has potential for success.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Spencer, Sabrina Leigh — University of Colorado
- Study coordinator: Spencer, Sabrina Leigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.