Understanding how cell surface proteins help build neural circuits in the brain
Official title: Cell surface protein dynamics in neural circuit assembly
Funded at Stanford University · NIH-11012352 · Data updated 2026-11-12
This study looks at how certain proteins on the surface of cells help brain connections form in fruit flies, which could teach us more about how our brains develop and work.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | January 17, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $128,331 |
| NIH project number | 5K99DC021195-02 |
| Project ID | NIH-11012352 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting neural circuit function, such as neurodevelopmental disorders or age-related cognitive decline.
✕Less likely to help
Patients with conditions unrelated to neural circuit assembly or those who do not have a central nervous system disorder may not benefit from this research.
What this research studies
This research investigates the role of cell surface proteins (CSPs) in the development of neural circuits within the brain. By studying the dynamics of these proteins in the Drosophila olfactory system, the research aims to uncover how CSPs facilitate the connections between neurons during critical developmental stages. The approach involves observing how CSPs are internalized and how this process affects their signaling and function in real-time. This could provide insights into the fundamental mechanisms of brain development and function.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of neural circuit assembly, potentially informing treatments for neurological disorders.
How similar studies have gone: Previous research has shown success in understanding neural circuit assembly through the study of cell surface proteins, making this approach promising yet still exploring novel aspects.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Mclaughlin, Colleen — Stanford University
- Study coordinator: Mclaughlin, Colleen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.