Understanding how cell surface proteins communicate and affect cell behavior
Deciphering the functional role of actin-spectrin-based membrane skeleton in subcellular compartmentalization of signaling proteins and cell signal transduction
This study is looking at how certain proteins on the surface of cells work together to help cells grow, survive, and communicate, which could lead to new treatments for diseases like cancer and brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-10890015 on NIH RePORTER |
What this research studies
This research investigates the roles of specific proteins on cell surfaces that respond to external signals, which are crucial for regulating cell growth, survival, and communication. By examining how these proteins interact and form organized clusters, the study aims to uncover the mechanisms that influence cell signaling pathways. This could lead to better understanding of diseases like cancer and neurodegenerative disorders, potentially informing the development of targeted therapies. The research employs advanced biochemical and biophysical techniques to analyze these interactions at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers or neurodegenerative disorders that may be influenced by cell signaling pathways.
Not a fit: Patients with conditions unrelated to cell signaling or those not diagnosed with cancer or neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for various cancers and neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding cell signaling pathways and their implications in disease, suggesting that this approach could yield significant insights.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Zhou, Ruobo — Pennsylvania State University, the
- Study coordinator: Zhou, Ruobo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.