Understanding how cell structures called microtubules are controlled by kinesin proteins
Mechanism of Microtubule Dynamics Regulation by Kinesins
This project explores how tiny proteins called kinesins control the growth and shrinkage of cell structures called microtubules, which is important for understanding and treating cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11087610 on NIH RePORTER |
What this research studies
Our cells rely on tiny internal structures called microtubules, which constantly grow and shrink, much like building blocks being assembled and disassembled. Proteins called kinesins help control this process, which is vital for many cell functions, including how cells divide. When this control goes wrong, it can contribute to diseases like cancer. This project aims to uncover the exact molecular steps that allow kinesins to regulate microtubules, and how these interactions affect cell behavior. By using advanced imaging techniques, we hope to see how kinesins change microtubule structures and how these changes are communicated throughout the cell, which could reveal new ways to target cancer cells.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future clinical applications would aim to help patients with various types of cancer.
Not a fit: Patients without cancer or those whose cancer does not involve microtubule dysfunction would likely not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could identify new targets for developing anti-cancer drugs by better understanding how cancer cells grow and divide.
How similar studies have performed: While the general roles of kinesins and microtubules are known, the precise molecular mechanisms and conformational changes explored in this project are still not fully understood, making this a novel area of investigation.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Sosa, Hernando Jose — Albert Einstein College of Medicine
- Study coordinator: Sosa, Hernando Jose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.