Understanding how cell size and Wnt signaling are controlled
The dynamics and underlying mechanisms controlling cell size and canonical Wnt signaling
This study is looking at how certain signals in our cells help control their size and growth, which is important for understanding development and cancer, and it aims to find out how these signals work together, so we can learn more about diseases like cancer and potentially improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10878827 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate cell size and the Wnt signaling pathway, which is crucial for development and cancer. By using advanced techniques like single molecule imaging and in vitro systems, the team aims to uncover how Wnt signals interact with proteins that control cell growth. The study will also utilize mathematical modeling to analyze the dynamics of these processes, providing insights into cellular behavior and function. Patients may benefit from a deeper understanding of how these pathways contribute to diseases, particularly cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or conditions related to abnormal cell growth and differentiation.
Not a fit: Patients with conditions unrelated to cell growth or Wnt signaling may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers by targeting the Wnt signaling pathway.
How similar studies have performed: Previous research has shown success in understanding cellular signaling pathways, making this approach promising yet still exploring new aspects of the Wnt pathway.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Kirschner, Marc Wallace — Harvard Medical School
- Study coordinator: Kirschner, Marc Wallace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.