Understanding how cell size affects cell division
Scaling of transcript abundance with cell size and the commitment to cell division
This study is looking at how the size of cells affects when they decide to divide, which could help us understand more about cell growth and its connection to diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10849827 on NIH RePORTER |
What this research studies
This research investigates the relationship between cell size and the process of cell division, focusing on how cells determine when they are large enough to divide. By examining the expression levels of various mRNAs as cells grow, the study aims to uncover mechanisms that control cell size and division. The researchers will explore the concept of 'super-scaling' and 'sub-scaling' of gene expression, which may reveal why certain genes promote or inhibit cell division based on cell size. This could lead to insights into cellular growth patterns and their implications for diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal cell growth or division, such as cancer patients.
Not a fit: Patients with stable, non-proliferative conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for controlling cell growth and division, which may have implications for cancer treatment and other growth-related disorders.
How similar studies have performed: While the specific scaling model being tested is novel, previous research has shown that understanding cell growth and division mechanisms can lead to significant advancements in cancer treatment.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Futcher, Bruce Bruce — State University New York Stony Brook
- Study coordinator: Futcher, Bruce Bruce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.