Understanding How Cell Signals Work in Disease
Structures and Interactions of Chemokine Receptors
This research aims to understand how certain cell signals, called chemokines, and their receptors contribute to various diseases, with the goal of finding new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11088706 on NIH RePORTER |
What this research studies
Our long-term goal is to uncover the detailed ways that chemokines and their receptors function in different health problems. We are working to turn this knowledge into new treatment approaches that could benefit patients. Recently, we designed new molecules that act on a specific receptor, CXCR4, and have been studying how they work in models of neurodegenerative disease. We are also exploring new ways to improve these molecules to create potential new medicines.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients at this stage, but it is relevant to individuals living with various conditions impacted by cell signaling pathways.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to the development of entirely new medications and treatment strategies for a range of diseases where chemokine signaling plays a role.
How similar studies have performed: This project has been continuously funded and successful for over two decades, indicating significant progress and promising results in understanding chemokine receptor mechanisms.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: An, Jing — University of California, San Diego
- Study coordinator: An, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.